MEGANUCLEASE VARIANTS CLEAVING THE GENOME OF A PATHOGENIC NON-INTEGRATING VIRUS AND USES THEREOF

• 收藏
• 分享

专利权人:

André Choulika;Frédéric Cedrone;Julianne Smith

发明人:

André Choulika,Frédéric Cedrone,Julianne Smith

申请号：

US13322266

公开号：

US20120171191A1

申请日:

2010.05.26

申请国别(地区):

US

年份:

2012

代理人:

摘要：

An I-CreI variant, wherein at least one of the two 1-Cre1 monomers has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG core domain situated from positions 26 to 40 and 44 to 77 of I-CreI, said variant being able to cleave a DNA target sequence from the genome of a non-integrating virus, in particular herpes simplex virus (HSV) or Hepatitis B virus (HBV) for use in genome engineering and for in vivo and ex vivo (gene cell therapy) genome therapy as well as the treatment of a virus infection.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/