LI, WEN SEN,THORNTON, JOHN E.,GUO, ZHENRONG,SWAMINATHAN, SHANKAR
申请号：
HU0300693
公开号：
HU229348B1
申请日:
2001.03.12
申请国别(地区):
HU
年份:
2013
代理人:
摘要：
The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opended epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a threefold increase in yield over prior processes for preparing the desired epothilone analogs.
