Baumbach, William R.,Sherman, Darren R.,Burgermeister, Robert
申请号：
AU2016202636
公开号：
AU2016202636B2
申请日:
2016.04.26
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2016202636B220170608.pdf#####BALLOON CATHETER SYSTEMS FOR DELIVERY OF DRY DRUG DELIVERY VESICLES TO A VESSEL IN THE BODY ABSTRACT A method of treating a lesion in a blood vessel of a patient comprising the steps of: providing balloon catheter system comprising: a catheter body (22) characterized by a distal portion and a proximal portion； a first balloon (18) disposed on the distal portion of the catheter body (22), said first balloon (18) having a porous wall portion, said porous wall portion having pores with a diameter of about 0.1 to 5 microns； providing a reservoir (24) of lyophilized micelles with rapamycin encapsulated in the micelles； providing a reservoir of aqueous solution suitable for mobilizing the micelles within the micelle reservoir (24)； mixing the aqueous solution with the micelles to wet and mobilize the micelles, such that the micelles have a particle size of 40 to 250 nm (.04 to .250 micron)； and delivering the micelles to the lesion, through the wall of balloon (18), by injection the micelles into the balloon (18) and pressurizing the balloon (18) to a pressure of 6 to 12 atmospheres to force the micelles through the porous wall portion of the balloon (18) into the blood vessel.
