The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.本發明關於3-({3-(4-氯苯基)-5-側氧基-4-[(2S)-3,3,3-三氟-2-羥丙基]-4,5-二氫-1H-1,2,4-三唑-1-基}甲基)-1-[3-(三氟甲基)-吡啶-2-基]-1H-1,2,4-三唑-5-甲醯胺、3-({3-(4-氯苯基)-5-側氧基-4-[(2S)-3,3,3-三氟-2-羥丙基]-4,5-二氫-1H-1,2,4-三唑-1-基}甲基)-1-[2-(三氟甲基)-苯基]-1H-1,2,4-三唑-5-甲醯胺及3-({3-(4-氯苯基)-5-側氧基-4-[(2S)-3,3,3-三氟-2-羥丙基]-4,5-二氫-1H-1,2,4-三唑-1-基}甲基)-1-(3-氯吡啶-2-基)-1H-1,2,4-三唑-5-甲醯胺之前驅藥、該等化合物之製備方法、含有該等化合物之醫藥組成物、及該等化合物或組成物用於治療及/或預防疾病，特別用於治療及/或預防腎和心血管疾病之用途。
