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POROUS SILICA PARTICLES FOR USE IN A COMPRESSED PHARMACEUTICAL DOSAGE FORM
专利权人:
Nanologica AB
发明人:
Chunfang Zhou,Xin Xia,Paulina Paszkiewicz,Adam Feiler,Hans Lennernäs,Nerea Arriaga Garcia
申请号:
US16613764
公开号:
US20200078307A1
申请日:
2019.03.11
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to a compressed pharmaceutical dosage form comprising one or more active pharmaceutical ingredients at a concentration between 2 and 15% w/w, porous particles, having a diameter between 1 and 100 μm, at a concentration between 10 and 50% w/w and optionally one or more excipients. The active pharmaceutical ingredient is in admixture with and/or loaded into said particles, whereby a ratio of unloaded versus loaded ingredient is between 100:1 and 1:100. The porosity of the dosage form is more than 5% and less than 45% and the hardness of the dosage form is more than 5 N and less than 30 N using a Schleuniger hardness type tester.
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