An injection device 110 comprises a locking mechanism between a syringe carrier and an end cap 111 of the injection device. The cap inhibits movement of the syringe carrier and syringe 114 towards an exit aperture 128 of the injection device when the cap is located in its closed position on the injection device. A needle shield 123 located on the needle of the syringe is removed by rotating the cap whilst the locking mechanism remains engaged. On removal of the cap, the locking mechanism is no longer so engaged and the syringe and syringe carrier can move towards the exit aperture. This assists in preventing damage to the syringe prior to actuation of the injection device.