AGENTS DE MIGRATION A TRAVERS LA BARRIERE HEMATO-ENCEPHALIQUE ET UTILISATIONS ASSOCIEES

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专利权人:

NATIONAL RESEARCH COUNCIL OF CANADA

发明人:

CHAKRAVARTHY, BALU,STANIMIROVIC, DANICA,DUROCHER, YVES

申请号：

CA3052058

公开号：

CA3052058A1

申请日:

2018.01.30

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

A brain-penetrating composition of amyloid-ß binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-ß targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.

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