GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
HENLEY, NICHOLAS PAUL
申请号：
CA3040584
公开号：
CA3040584A1
申请日:
2017.08.31
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to a crystalline hydrate of the compound (2S,3R)-isopropyl 2-(((2-(l,5-dimethyl-6-oxo-l,6-dihydropyridin-3-yl)-l-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl)amino)-3-hydroxybutanoate edisylate and to its use in the treatment of various disorders for which a BET inhibitor is indicated, in particular inflammatory and autoimmune diseases, and cancers. Processes for the manufacture of this crystalline form and pharmaceutical compositions comprising the crystalline form are also disclosed and form part of the present invention.
