SVENSTRUP, NIELS,SIMONSEN, KLAUS BÆK,RASMUSSEN, LARS KYHN,JUHL, KARSTEN,LANGGÅRD, MORTEN,WEN, KATE,WANG, YAZHOU
申请号：
SG11201502728W
公开号：
SG11201502728WA
申请日:
2012.10.09
申请国别(地区):
SG
年份:
2015
代理人:
摘要：
This invention is directed to 6-[4-METHYL-1-(PYRlMIDIN-2-YLMETHYL)PYRROLIDIN-3-YL]-3-TETRAHYDROPYRAN-4-YL-7H-IMIDAZO[1,5-A]PYRAZIN-8-ONE and pharmaceutically acceptable acid addition salts thereof, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of invention. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of the invention. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).
