PROBLEM TO BE SOLVED: To provide a skin external preparation having a new emulsifier type capable of being suitably applied to a cosmetic, a pharmaceutical composition and the like, and a production method of the skin external preparation.SOLUTION: An O/W/O emulsifier-type skin external preparation contains an amphipathic molecule, water and oil, where the aqueous phase of the skin external preparation comprises an aqueous phase having a vesicle and an oil-in-water phase having a lamellar liquid crystal emulsion. A production method of the skin external preparation comprises the steps of: dispersing an aqueous phase previously prepared from the vesicle and the lamellar liquid crystal emulsion to obtain a dispersion liquid and dispersing the obtained dispersion liquid in an oil phase to obtain a skin external preparation.COPYRIGHT: (C)2014,JPO&INPIT【課題】化粧料、医薬組成物等に好適に適用し得る、新たな乳化剤型を有する皮膚外用剤、及び該皮膚外用剤の製造方法の提供。【解決手段】両親媒性分子、水、油分を含有するO/W/O型乳化剤型の皮膚外用剤であって、前記皮膚外用剤の水相が、ベシクルを有する水相と、ラメラ液晶エマルションを有する水中油相とを含む皮膚外用剤、及び水相に予め調製したベシクル及びラメラ液晶エマルションを分散させ、分散液を得る工程、及び前記得られた分散液を油相中に分散させ、皮膚外用剤を得る工程、を含む皮膚外用剤の製造方法。【選択図】なし
