A system for disinfecting an enclosed area may include at least one ultraviolet (UV) light and a fogging device which may include a portable housing, an atomizing disinfectant generator carried by the portable housing, and a processor carried by the portable housing. The processor may be configured to initiate a treatment cycle during which the atomizing disinfectant generator dispenses atomized disinfectant fluid into the enclosed area, after a first time period activate the at least one UV light while the atomized disinfectant fluid is being dispensed into the enclosed area, and after a second time period later than the first time period deactivate the at least one UV light and prior to completion of the treatment cycle.
