An airway assessment and intubation guidance system, device and method that is portable, simple to use, and effective in reliably locating the trachea within the neck of a wide variety of patients and independent of fluids that may be found within the trachea. The system permits an objective assessment of the likelihood of a difficult intubation, and further provides, depending upon the embodiment, both visual and audible feedback regarding the location of a compatible stylet relative to the trachea.