Carrillo Molina, Jorge,Clotet Sala, Bonaventura,Blanco Arbues, Julia M.
申请号：
AU2018266847
公开号：
AU2018266847A1
申请日:
2018.05.09
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
The present invention relates to Fc-fusion protein derivatives against HIV with enhanced yield in mammalian cells, extended antiviral and immunomodulatory activities. The Fc-fusion protein derivatives of the present invention are characterized for: (i) blocking the entry of human immunodeficiency virus (HIV) into host cells, (ii) eliciting effector functions through the activation of natural killer (NK) and other immune system cells, (iii) having a high yield production in mammalian cells and (iv) having extended activity in vivo. The present invention further relates to nucleic acids, vectors and host cells expressing said Fc- fusion protein derivatives, as well their therapeutic and diagnostic applications in human health.
