LEE, LAIN TZE,李连滋,李連滋,CHANG, SHAU FENG,张秀凤,張秀鳳,LIN, CHIA YU,林家伃,WU, HUI YEN,吴慧眼,吳慧眼,CHEN, SHU FENG,陈淑丰,陳淑豐,YEH, JINUN BAN,叶俊邦,葉俊邦
申请号：
TW097151799
公开号：
TWI370736B
申请日:
2008.12.31
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
The invention provides a pharmaceutical composition for treating hepatitis B, including: an effective amount of proanthocyanidins oligomer； and a pharmaceutically acceptable carrier or salt, wherein a formula of the monomer of the proanthocyanidins is shown in the following: and wherein R1 is OCH3, R2 is OH and R3 is H, or R1 is OH and R2 and R3 both are H, or R1 and R2 both are OH and R3 is H, or R1, R2 and R3 all are OH, and R4 is 3-(&agr； )-OH, 3-(&bgr； )-OH, 3-(&agr； )-O-sugar or 3-(&bgr； )-O-sugar. Bonding between adjacent monomers take place at C4, C8 Carbon-carbon bond or C2, C7 oxygen bond of A type or C4, C8 or C4, C6 Carbon-carbon bond of B type or C type of proanthocyanidins. And the polymerized number is from 2 to 30.本發明提供一種用以治療B型肝炎的藥學組合物，包括：一有效量原花青素聚合物；以及一藥學上可接受之載體或鹽類，其中該原花青素聚合物之單體分子式如下所示：；而其中R1為OCH3、R2為OH且R3為H，或R1為OH且R2與R3皆為H，或R1與R2皆為OH且R3為H，或R1、R2與R3皆為OH，而R4為3－(α)－OH、3－(β)－OH、3－(α)－O－sugar或3－(β)－O－sugar，而該原花青素聚合物之單體之連接為C4、C8碳鍵、C4、C6碳鍵或C2、C7氧鍵及其異構物，又該原花青素之聚合度為2－30。
