Jang-Hee Hahn,Chang-Seo Park,In-Young Ko,Byong-Ik Chun,Byoung-Chul Kim
申请号：
US14422643
公开号：
US09464112B2
申请日:
2013.08.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided are small peptide fragments derived from the NF-κB p65 subunit and a pharmaceutical or cosmetic composition comprising the same. The peptides have a NF-κB inhibitory activity, through controlling the transcription-activation of NF-κB. The peptides inhibit the expressions of pro-inflammatory mediators, which are induced by NF-κB, and also inhibit the transmigration of leukocytes, thereby exhibiting an anti-inflammatory activity. Especially, the peptides have excellent inhibitory activities against dermatitis and skin aging. And also, the peptides inhibit base membrane invasion of cancer cells, thereby exhibiting an inhibitory activity against the growth and/or metastasis of cancer cells.
