The present invention provides small peptide fragments derived from the p65 subunit of NF-κB, and a pharmaceutical composition or cosmetic composition comprising same. The peptides adjust the transactivation function of NF-κB so as to have NF-κB inhibitory activity. The peptides inhibit the expression of various inflammatory mediator molecules, the expression of which is induced by NF-κB activity, and inhibit the extravasation of white blood cells so as to have an anti-inflammatory activity. Particularly, the peptides have excellent inhibitory activity against skin inflammation and skin aging. Further, the peptides inhibit the vascularization and permeation of the basement membrane of cancer cells so as to have an inhibitory activity against the growth and metastasis of cancer cells.La présente invention concerne de petits fragments peptidiques dérivés de la sous-unité p65 de NF-κB, et une composition pharmaceutique ou une composition cosmétique les comprenant. Lesdits peptides ajustent la fonction de transactivation de NF-κB de sorte à présenter une activité inhibitrice de NF-κB. Lesdits peptides inhibent lexpression de diverses molécules médiatrices inflammatoires, dont lexpression est induite par activité de NF-κB, et inhibent lextravasation des globules blancs de sorte à présenter une activité anti-inflammatoire. Lesdits peptides présentent en particulier une excellente activité inhibitrice contre linflammation de la peau et le vieillissement de la peau. En outre, lesdits peptides inhibent la vascularisation et la perméabilité de la membrane basale de cellules cancéreuses de sorte à présenter une activité inhibitrice contre la croissance et la métastase de cellules cancéreuses.본 발명은 NF-κB의 p65 서브유닛으로부터 유래된 작은 펩타이드 단편(small peptide fragments) 및 이를 포함하는 약학 조성물 또는 화장료 조성물을 제공한다. 상기 펩타이드는 NF-κB의 전사 촉진 기능을 조절함으로써 NF-κB 억제 활성을 갖는다. 상기 펩타이드들은 NF-κB 활성에 의해 발현이 유도되는 다양한 염증 매개분자의 발현을 억제하고 백혈구의 혈관외유출을 억제함으로써 항-염증 활성을 갖는다. 특히, 상기 펩타이드들은 피부 염증 및 피부 노화에 대한 우수한 억제활성을 갖는다. 또한,
