Stephen Mark Robbins,Jennifer Rahn,Donna Lorraine Senger
申请号：
US12950855
公开号：
US08530429B2
申请日:
2010.11.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A method of diagnosing and treating a human glioblastoma multiforme (GBM) brain tumor in a subject is disclosed. The method includes administering to the subject, an effective amount of composition having a peptide 12-20 amino acid residues in length and selected for its ability to bind preferentially to a subtype of human GBM cells identified as brain tumor initiating cells (BTICs) or highly invasive glioma cells (HIGCs). Also disclosed are a phage-display screening method for identifying such therapeutic peptides, and peptides that hind specifically to BTICs or HIGCs.
