POXEL;INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
发明人:
MESANGEAU, DIDIER,LEVERVE, XAVIER,CRAVO, DANIEL
申请号：
ES10735245
公开号：
ES2551777T3
申请日:
2010.07.16
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compound of formula (I): ** Formula ** in which: R1, R2, R3, and R4 are independently selected from the groups: - H, - (C1-C20) alkyl not substituted or substituted by halogen , (C1-C5) alkyl, (C1-C5) alkoxy, (C3-C8) cycloalkyl, (C2-C20) alkenyl not substituted or substituted by halogen, (C1-C5) alkyl, (C1-C5) alkoxy (C2-C20) unsubstituted or substituted by halogen, (C1-C5) alkyl, (C1-C5) alkoxy, - (C3-C8) cycloalkyl unsubstituted or substituted with (C1-C5) alkyl, (C1-C5) alkoxy ), - (C3-C8) heterocycloalkyl having one or more heteroatoms selected from N, O, S, unsubstituted or substituted with (C1-C5) alkyl, (C1-C5) alkoxy, - aryl (C6-C14) alkyl (C1-C20) unsubstituted or substituted with amino, hydroxy, thio, halogen, (C1-C5) alkyl, (C1-C5) alkoxy, (C1-C5) alkylthio, (C1-C5) alkylamino, aryl (C6-) C14) oxy, (C6-C14) aryl (C1-C5) alkoxy, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxymethyl, - (C6-C14) aryl unsubstituted or substituted with amino, hydroxy, thio, halogen, (C1-C5) alkyl, (C1-C5) alkoxy, (C1-C5) alkylthio, (C1-C5) alkylamino, aryl (C6-C14) oxy, aryl (C6-C14) (C1-C5) alkoxy, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxymethyl, - (C1-C13) heteroaryl having one or more heteroatoms selected from N, O, S, unsubstituted or substituted with amino, hydroxy, thio, halogen , (C1-C5) alkyl, (C1-C5) alkoxy, (C1-C5) alkylthio, (C1-C5) alkylamino, (C6-C14) oxy, aryl (C6-C14) (C1-C5) alkoxy, cyano, trifluoromethyl, carboxy, carboxymethyl or carboxy ethyl, R1 and R2, on the one hand, and R3 and R4, on the other hand, being able to form with the nitrogen atom a cycle of n members in the ring (n between 3 and 8) comprising or not comprising one or more heteroatoms selected from N, O, S and which may be substituted with one or more of the following groups: amino, hydroxy, thio, halogen, (C1-C5) alkyl, (C1-C5) alkoxy ), (C1-C5) alkylthio, (C1-C5) alkylamino, aryl (C6-C14) oxy, aryl (C6-C14) (C1-C5) alkoxy, cyano, trifluoromethyl, carboxy, carboxymet
