#$%^&*AU2019240611A120191017.pdf#####Abstract Disclosed herein are conjugate compounds or pharmaceutically acceptable salts thereof, their pharmaceutical compositions and methods of using the same. In particular, disclosed herein are multi-ligand drug conjugates, especially multi-ligand conjugates capable of inducing endocytosis, as well as their pharmaceutical compositions, methods of using the same in delivering payloads to subjects in need thereof, and methods of using the same in treating diseases, including but are not limited to, cancers, immunological diseases, cardiovascular diseases, metabolic diseases, and neurological diseases.