ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ОСНОВЕ ФИТОНУТРИЕНТОВ С ПОВЫШЕННОЙ БИОДОСТУПНОСТЬЮ, ОБЛАДАЮЩАЯ ПРОТИВООПУХОЛЕВОЙ АКТИВНОСТЬЮ, И СПОСОБ ЕЕ ПОЛУЧЕНИЯ (ВАРИАНТЫ)
KISELEV, Vsevolod Ivanovich,КИСЕЛЕВ, Всеволод Иванович
申请号：
RURU2013/000568
公开号：
WO2014/062083A1
申请日:
2013.07.19
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The invention relates to the field of pharmacy and concerns novel pharmaceutical compositions for peroral delivery of phyto-nutrients. The pharmaceutical composition comprises at least one phyto-nutrient from the following series: epigallocatechin-3-gallate, diindolylmethane, genestein, resveratrol, curcumine, and a solubilizer - a polyvinylcaprolactam/polyvinylacetate/polyethyleneglycol graft copolymer with an average molecular mass of 90000-140000 g/mol at a mass ratio of at least one phyto-nutrient and solubilizer of 1/5 to 1/1. Furthermore, the composition can additionally comprise a pharmaceutically acceptable carrier. The method for producing the above-mentioned pharmaceutical composition according to the first alternative consists in that the solubilizer is dissolved in an organic solvent, at least one phyto-nutrient is dissolved in the same organic solvent, the resulting solutions are mixed and the solvent is distilled off in vacuo, wherein, according to the invention, after the solutions are mixed, the resulting mixture is heated to 45-50̊C with constant stirring and, after distillation, the product is dried in vacuo. Ethanol, or acetone, or isopropanol can be used as the organic solvent. The method for producing the above-mentioned pharmaceutical composition according to the second alternative consists in the dry mixing of the powders of the solubilizer and of at least one phyto-nutrient. The resulting compositions are stable and have high bioavailability.Linvention se rapporte au domaine de la pharmacie et concerne de nouvelles compositions pharmaceutiques pour ladministration par voie orale de phytonutriments. La composition pharmaceutique comprend au moins un phytonutriment choisi dans le groupe comprenant : épihalocatéchol-3-gallate, diindolylméthane, génistéine, resveratrol, curcumine, et un solubilisant consistant en un copolymère greffé polyvinylcaprolactame / polyvinylacétate / polyéthylène glycol ayant un poids moléculaire moyen de 90000-140000 g
