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Co-Processed Excipient Compositions
专利权人:
Vinay Umesh Rao
发明人:
Vinay Umesh Rao,Jagdish Balasubramaniam,Rama Krishna Haldar
申请号:
US13266341
公开号:
US20120178822A1
申请日:
2010.04.26
申请国别(地区):
US
年份:
2012
代理人:
摘要:
An oral solid dosage form having improved dissolution profile and a method of producing the same are provided. The present invention particularly provides a co-processed excipient composition and a method of producing the same. More particularly, it relates to a co-processed binary mixture of crosslinked polyvinylpyrrolidone and calcium silicate wherein the weight ratio of crosslinked polyvinylpyrrolidone and calcium silicate is in the range of 1:1 to 20:1. The binary mixture when combined with a poorly soluble drug enhances its dissolution and extent of release.
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