BIOMATÉRIAUX COMPRENANT DES PEPTIDES SE LIANT À L'ACIDE HYALURONIQUE ET DES PEPTIDES SE LIANT À LA MATRICE EXTRACELLULAIRE POUR DES APPLICATIONS ASSOCIÉES AU GÉNIE TISSULAIRE ET AU POUVOIR DE RÉTENTION DE L'ACIDE HYALURONIQUE
The present invention provides novel biomaterial compositions and methods having a technology to improve retention of hyaluronic acid (HA). The biomaterial compositions utilize small HA binding peptides and extracellular matrix binding (ECM) peptides that are tethered to synthetic biocompatible polymers. When tethered to the polymers, the peptide region allows the polymers to bind to HA and to tissues such as cartilage. The novel biomaterial compositions can be used to coat or chemically modify cartilage or tissues with a biologically compatible polymer having HA binding peptides, which allow HA to bind to the surface of the cartilage or tissues. Methods of using same are also provided.
