James R. Baker, JR.;Yuehua Zhang;Thommey P. Thomas;James R. Baker;Ankur Mahesh Desai; JR.
发明人:
James R. Baker, JR.,Yuehua Zhang,Thommey P. Thomas,Ankur Mahesh Desai
申请号：
US13383378
公开号：
US20120177593A1
申请日:
2010.07.20
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.
