USE OF TLR AGONISTS AND/OR TYPE 1 INTERFERONS TO ALLEVIATE TOXICITY OF TNF-R AGONIST THERAPEUTIC REGIMENS

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专利权人:

发明人:

Randolph J. Noelle,Ross M. Kedl,Cory L. Ahonen

申请号：

US13863460

公开号：

US20130302278A1

申请日:

2013.04.16

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Improved (safer and more effective) methods of therapy using TNF-R agonists, e.g., CD40 agonists are provided. These methods provide for the addition of an amount of a type 1 interferon and/or a TLR agonist that is effective to prevent or reduce the toxicity (liver toxicity) that may otherwise result in some patients of the TNF-R agonist is used as a monotherapy (without the type 1 interferon and/or TLR agonist).

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中国工程科技知识中心

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http://www.ckcest.cn/home/