ANTICORPS MONOCLONAUX DE STIMULATION IMMUNITAIRE CONTRE L'INTERLEUKINE-2 HUMAINE

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专利权人:

UNIVERSITAT ZURICH;NOVARTIS AG

发明人:

ZOU, CHAO,BOYMAN, ONUR,ARENAS-RAMIREZ, NATALIA

申请号：

CA2954476

公开号：

CA2954476A1

申请日:

2015.07.10

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The invention relates to a human lnterieuldn-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hlL-2 inhibits binding of hlL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006； the binding to hIL-2 is characterized by a dissociation constant (KD)= 7,5 nmol/L； the binding to hIL-2 is characterized by an off-rate (?off)= 1x10-4 s-1 and/or the antibody displays no measurable cross-reactivity to murine IL-2.

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