TETRAHYDROFOLATES ISOMERIQUEMENT PURS MARQUES AU 18F

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专利权人:

MERCK PATENT GMBH

发明人:

MOSER, RUDOLF,GROEHN, VIOLA,MUELLER, CRISTINA,SCHIBLI, ROGER,AMETAMEY, SIMON,BOSS, SILVAN

申请号：

CA3057042

公开号：

CA3057042A1

申请日:

2018.03.19

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present invention is directed towards isomerically pure 18F-labelled (6S)-or (6R)-5-methyltetrahydrofolate radiopharmaceuticals, wherein the phenyl group within the folate structure, has been replaced by an 18F-labelled N-heterocycle, for use in diagnostic imaging of a cell or population of cells expressing a folate-receptor in vitro or in vivo or for use in monitoring of cancer or inflammatory and autoimmune diseases and therapy thereof.

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