NEW DIHYDRO- OXAZOLOBENZODIAZ EPINONE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
- 专利权人:
- 发明人:
- 申请号：
- IN550/DEL/2012
- 公开号：
- IN292522B
- 申请日:
- 2012.02.28
- 申请国别(地区):
- IN
- 年份:
- 2018
- 代理人:
- 摘要：
Dihydro-oxazolobenzodiazepinone derivatives (I) are new. Dihydro-oxazolobenzodiazepinone derivatives of formula (I) and their positional isomers, enantiomers, diastereoisomers or addition salts with acids, solvates, complexes or adducts, are new. R1 : H or 1-4C alkyl R2 : 1-4C alkyl and R3 : (hetero)aryl. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Neuroleptic Antidepressant Neuroprotective Nootropic Antiparkinsonian Anticonvulsant Tranquilizer Vulnerary Cerebroprotective. MECHANISM OF ACTION : gamma -Aminobutyric acid (GABA) receptor agonist. The GABA receptor agonistic activity of (I) was tested in human embryonic kidney (HEK-293) cells. The result showed that 5-(6-fluoro-1-benzothien-2-yl)-8-methyl-1,9-dihydro-2H-[1,3]oxazolo[4,5-h][2,3]benzodiazepin-2-one exhibited an IC 5 0value of 100 nM.
[EP2497774A1]
- 来源网站：
- 中国工程科技知识中心
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- New dihydro-oxazolobenzodiazepinone compounds, a process for their preparation and pharmaceutical compositions containing them
- New dihydro-oxazolobenzodiazepinone compounds, a process for their preparation and pharmaceutical compositions containing them
- DIHYDRO-OXAZOLOBENZODIAZEPINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS
- Dihydrooxazolobenzodiazepinone derivatives, processes for their preparation and pharmaceutical compositions containing these compounds
- DIHYDRO-OXOZOLOBENZODIAZEPINONE COMPOUNDS,A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
