Pyrrolobenzodiazepines and conjugates thereof

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专利权人:

MEDIMMUNE LIMITED

发明人:

Flygare, John,Pillow, Thomas,Howard, Philip,Wei, Binqing

申请号：

NZ71074614

公开号：

NZ710746A

申请日:

2014.03.13

申请国别(地区):

NZ

年份:

2018

代理人:

摘要：

The present invention relates to a pyrrolobenzodiazepines (PBD), in particular pyrrolobenzodiazepines having a linker group connected to a cell binding agent. Further or alternatively, the invention relates to conjugates of formula Ia, pharmaceutical compositions thereof, use thereof in the preparation of a medicament for the treatment of a proliferative disease (in particular breast cancer), and/or PBD compounds IIa, IIIa, IVa and/or Va.

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中国工程科技知识中心

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