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Use of 2-phenyl-1, 2-ethanediol- (di) carbamates for treating epileptogenesis and epilepsy
专利权人:
Janssen Pharmaceutica; N.V.
发明人:
Zhao, Boyu,Twyman, Roy E,Choi, Yong Moon,Plata-Salaman, Carlos R.,Novak, Gerald P.,White, H. Steve,Gordon, Robert
申请号:
AU2005287174
公开号:
AU2005287174B2
申请日:
2005.09.15
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
This invention is directed to methods for preventing, treating, reversing,inhibiting or arresting epilepsy and epileptogenesis in a subject comprisingadministering to the subject in need thereof a therapeutically effective amountof a compound selected from the group consisting of Formula (I) and Formula (II),or a pharmaceutically acceptable salt or ester thereof,: Formula (I) Formula(II) wherein phenyl is substituted at X with one to five halogen atoms selectedfrom the group consisting of fluorine, chlorine, bromine and iodine and, R,R, R, R, R and R are independentlyselected from the group consisting of hydrogen and C-Calkyl wherein C-C alkyl is optionally substituted withphenyl (wherein phenyl is optionally substituted with substituents independentlyselected from the group consisting of halogen, C-C alkyl,C-C alkoxy, amino, nitro and cyano).
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