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COMPOSITIONS AND METHODS RELATED TO SYNCHRONOUS SELECTION OF HOMING PEPTIDES FOR MULTIPLE TISSUES BY IN VIVO PHAGE DISPLAY
专利权人:
Mikhail Kolonin
发明人:
Mikhail Kolonin,Wadih Arap,Renata Pasqualini
申请号:
US13439172
公开号:
US20120270808A1
申请日:
2012.04.04
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Embodiments of the invention include methods for selecting in parallel (i.e., synchronously or simultaneously) peptides that target a number of organs, in which each peptide targets distinct tissues or organs. Typically, the methods of the invention provide for peptide selection in a Minimal number of subjects and still provides a selectively binding peptide. In certain aspects, methods of identifying peptides that bind to multiple selected tissues or organs of an organism may comprise the steps of administering a phage display library to a first subject obtaining a sample of two or more selected tissues obtaining phage displaying peptides that bind to the samples from the first subject enriching for peptides by administering phage isolated from the samples of the first subject to a second subject obtaining a sample of two or more selected tissues from the second subject and identifying the peptides displayed.
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