The invention relates to pharmaceutical compositions comprising of FRY polypeptides and nucleotides, methods to treat cancer, methods to diagnose cancer, and methods to determine the effectiveness of the treatment of cancer, as well as methods to differentiate stem cells.本発明は、FRYのポリペプチドおよびヌクレオチドを含む薬学組成物、癌を治療する方法、癌を診断する方法、癌の治療の有効性を決定する方法、ならびに幹細胞を分化させる方法に関する。