Determination of the susceptibility of zanamivir phosphonate congeners with anti-influenza activity and influenza virus to oseltamivir

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专利权人:

アカデミア シニカ

发明人:

ウォン， チー－ヒュイ,ファン， ジン－ミン,チェン， イー－シュン,シー， ジュン－ジー,ウォン, チー-ヒュイ,ファン, ジン-ミン,チェン, イー-シュン,シー, ジュン-ジー

申请号：

JP2013510261

公开号：

JP5947289B2

申请日:

2011.05.10

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of oseltamivir-resistant influenza viruses by competitive binding assays utilizing non-oseltamivir influenza virus neuraminidase inhibitors and oseltamivir carboxylate are provided. Influenza virus neuraminidase inhibitors coupled to sensors and useful for employment in the methods of the invention are disclosed. Novel phosphonate compounds active as neuraminidase inhibitors against wild-type and oseltamivir-resistant influenza strains of H1N1, H5N1 and H3N2 viruses are disclosed. An enantioselective synthetic route to preparation of these phosphonate compounds via sialic acid is provided.

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