This disclosure relates generally to the field 0f anti-pathogenic agents, including a modified defensin molecule with anti-pathogen activity having a modification to the loop IB region. Genetically modified plants and their progeny or parts expressing or containing the modified defensin and anti-pathogen compositions for use in horticulture and agriculture and as animal and human medicaments are also provided. Defensins derived from Nicotiana suavolens are also provided.
