592276 Disclosed is a solid oral extended release pharmaceutical dosage form, comprising a melt formed multi particulate extended release matrix formulation, comprising at least one poly(epsilon-caprolactone), and at least one active agent, wherein the at least one active agent comprises an opioid analgesic. Also disclosed is the process for making the extended release dosage form and the use of the form in the manufacture of a medicament for treating pain. Further disclosed is the use of poly(epsilon-caprolactone) as matrix forming material in opioid analgesics preparations to imparting to the solid oral extended release dosage form with a resistance to milling.
