Luc Juliaan Corina Van Rompaey;Alastair James Hodges;Koen Kurt Smits;Javier Blanc;Stephen Robert Fletcher;Christel Jeanne Marie Menet;Nolwenn Jouannigot
发明人:
Christel Jeanne Marie Menet,Nolwenn Jouannigot,Javier Blanc,Luc Juliaan Corina Van Rompaey,Stephen Robert Fletcher,Alastair James Hodges,Koen Kurt Smits
申请号：
US13055936
公开号：
US08853240B2
申请日:
2009.07.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
[1,2,4]triazolo[1,5-a]pyridine compounds are disclosed that have a formula represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis； and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g. diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6 and transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
