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COMPOUNDS USEFUL FOR the TREATMENT OF DEGENERATIVE and INFLAMMATORY DISEASES
专利权人:
GALAPAGOS N.V.
发明人:
CHRISTEL JEANNE MARIE MENET,JAVIER BLANC
申请号:
BRPI0916862
公开号:
BRPI0916862A2
申请日:
2009.07.24
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
A novel [1,2,4]triazolo[1,5-a]pyridine compound is disclosed that has a formula represented by the following: This compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g. diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6 and transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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