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tetracyclic compound
专利权人:
CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人:
KINOSHITA, KAZUTOMO,ASOH, KOHSUKE,FURUICHI, NORIYUKI,ITO, TOSHIYA,KAWADA, HATSUO,ISHII, NOBUYA,SAKAMOTO, HIROSHI,HONG, WOOSANG,PARK, MINJEONG,ONO, YOSHIYUKI,KATO, YASUHARU,MORIKAMI, KENJI,EMURA, TAKAS
申请号:
PE2011002060
公开号:
PE20121065A1
申请日:
2010.06.09
申请国别(地区):
PE
年份:
2012
代理人:
摘要:
A formula 1, wherein A1, A2, A3, A4, a7, A8, A9 and A10 are n, the rest are C; A5 is NR5, or s; R1 and R10 are h, cyanogen, halogen, and isocyclic 4-10 substitute or non substitute members respectively; R2 is h, C1-C8 tar, alquenilo c2-c8, cyanogen, halogen, etc.; R3 is h, Whether C1-C8 tar is replaced by 1 or more halides, 1 or more Oh, arilo C6-C10, cyanogen, etc.; R4 is h, C1-C8 tar, cycloquilo c3-c8, cyanogen, hydrogen poisoning, hydroxyl, etc.; R5 is h, C1-C8 tar, C1-C8 tar, C1-C8 tar, c2-c8 tar, etc.; R6 and R6 'are C1-C8, C8 and C8. Or form c3-c8 bike togetherHterocyclolaquilo, other of 4-10 members replaced or not replaced; R7 is h, halogeno, aloxyl C1-C8, aculfonilo C1-C8, nitro, etc.; R8 is h, C1-C8 replaced or not replaced C1-C8 tar, alquenilo c2-c8, cyclopentyl c3-c8, alcoxiilo C1-C8, oxo, Ciano, asphalt, etc.; R9 is h, asphalt C1-C8, Nile C8, C8, halogen-c8, etc There are others The preferred compound is 9 - (4-isopropyl-piperazin-1-il) - 6, 6-dimethyl-11-oxo-6, 11-dihydro-5h-benzo [b] carbazol-3-carbon. These compounds are ALC butyl inhibitors for cancer, metabolism and depression.REFERIDA A UN COMPUESTO DE FORMULA I, DONDE UNO DE A1, A2, A3, A4, A7, A8, A9 Y A10 ES N Y LOS RESTANTES C; A5 ES NR5, O, S; R1 Y R10 SON CADA UNO H, CIANO, HALOGENO, HETEROCICLOALQUILO DE 4-10 MIEMBROS SUSTITUIDO O NO; R2 ES H, ALQUILO C1-C8, ALQUENILO C2-C8, CIANO, HALOGENO, ENTRE OTROS; R3 ES H, ALQUILO C1-C8 SUSTITUIDO O NO CON 1 O MAS HALOGENOS, 1 O MAS OH, ARILO C6-C10, CIANO, ENTRE OTROS; R4 ES H, ALQUILO C1-C8, CICLOALQUILO C3-C8, CIANO, HIDROXICARBONILO, HIDROXILO, ENTRE OTROS; R5 ES H, ALQUILO C1-C8, ALQUILSULFONILO C1-C8, ALQUINILO C2-C8, ENTRE OTROS; R6 Y R6' SON CADA UNO ALQUILO C1-C8, ALQUENILO C2-C8, O JUNTOS FORMAN CICLOALQUILO C3-C8, HTEROCICLOALQUILO DE 4-10 MIEMBROS SUSTITUIDO O NO, ENTE OTROS; R7 ES H, HALOGENO, ALCOXILO C1-C8, ALQUILSULFONILO C1-C8, NITRO, ENTRE OTROS; R8 ES H, ALQUILO C1-C8 SUSTITUIDO O NO, ALQUENILO C2-C8, CICLOALQUILO C3-C8, ALCOXICARB
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