A needle stick safety syringe includes a plunger where a concentric coil spring is compressed against the inside front end of the plunger cavity and retained there by a stop which is incorporated at the distal end of the inner cylindrical plunger body. The stop is released when the plunger is pushed all the way forward, which causes the plunger to be engaged with the needle base through interconnecting means. The release is activated by holding the syringe in one hand allowing the needle to be retracted into the cylindrical plunger cavity and to prevent reuse.