Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.一種具有高可靠度之可吞食的事件標示器被提供。該可吞食的事件標示器的態樣包括一支撐件,一控制電路,一第一電化學物質,一第二電化學物質及一薄膜。此外,該可吞食的事件標示器可包括一或多個施加高可靠度給該可吞食的事件標示器的組成。又,該可吞食的事件標示器可包括一活性劑。在一些態樣中,該活性劑,譬如一藥學活性劑或一診斷劑,可與該薄膜相結合。