Dermal delivery compositions are provided. Aspects of the dermal delivery compositions include the presence of active active agent-calcium phosphate particle complexes, where these complexes include uniform, rigid, spherical nanoporous calcium phosphate calcium phosphate particles associated with one or more active agents. Also provided are methods of using the compositions in active agent delivery applications.本發明提供皮膚遞送組成物。該等皮膚遞送組成物之特點包括活性劑-磷酸鈣粒子複合物之存在,其中這些複合物包括與一或多種活性劑結合之均勻剛性球形奈米孔洞磷酸鈣粒子。本發明也提供將該等組成物使用於活性劑遞送應用之方法。