Mayo Foundation for Medical Education and Research
发明人:
Christopher G.A. McGregor,Guerard W. Byrne
申请号：
US15494976
公开号：
US20170360906A1
申请日:
2017.04.24
申请国别(地区):
US
年份:
2017
代理人:
摘要：
This document provides methods and materials involved in reducing cardiac xenograft rejection. For example, methods and materials for preparing transgenic pigs expressing reduced or no endogenous Sda or SDa-like glycans derived from the porcine β1,4 N-acetyl-galactosaminyl transferase 2 (B4GALNT2) glycosyltransferase and/or reduced or no endogenous α-Gal antigens, methods and materials for modifying the xenograft recipient's immunological response to non-Gal antigens (e.g. CD46, CD59, CD9, PROCR, and ANXA2) to reduce cardiac xenograft rejection, and methods and materials for monitoring the progress of xenotransplant immunologic rejection are provided.
