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METHODS AND COMPOSITIONS FOR THE INHIBITION OF TRANSPLANT REJECTION
专利权人:
Amplimmune; Inc.
发明人:
Solomon Langermann,Linda Liu
申请号:
US14679505
公开号:
US20160039906A1
申请日:
2015.04.06
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Methods for modulating immune responses in a subject are provided. A preferred embodiment provides methods and compositions for reducing or inhibiting transplant rejection in a subject, preferably a human subject. Transplant rejection can be inhibited or reduced in a subject by administering an effective amount of B7-H4 polypeptide, fragments or fusions thereof to inhibit or reduce the biological activity of an immune cell or to reduce the amounts of proinflammatory molecules at a site of transplant. Th1, Th17 and Th22 cells are exemplary T cells that can be targeted for inhibition by B7-H4 polypeptides, fusion proteins or fragments thereof to inhibit or reduce inflammation.
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