The system has an exchangeable consumable magazine including magazine units, where each magazine unit (24) is provided with a piercing element (32), a test element (34), and transport elements (28). A transport mechanism acts on the transport elements for transporting the magazine in a magazine guide of a hand-held device. A positioning device positions the magazine unit in a specified functional position, where the positioning device is brought into engagement with transport elements by retaining elements. An independent claim is also included for a method for operating the analytical system for analyzing a body fluid for a blood sugar test.