A robotic punch system employs a robot unit (70) and a control unit (80). The robot unit (70) includes a robot (71) and an endoscopic punch (72) mounted to the robot (71). The endoscopic punch (72) includes a calibrated spatial alignment of an endoscope (73) and a punch (74). The control unit (80) commands the robot (71) for deploying the endoscopic punch (72) in executing a puncture of an anatomical tissue (92).