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ROR GAMMA (RORΓ) MODULATORS
专利权人:
리드 파마 셀 모델스 아이피 비.브이.
发明人:
칼스, 요세프 마리아 제라르두스 바르바라,나부르스, 샌더 베르나르두스
申请号:
KR1020167017849
公开号:
KR1020160105413A
申请日:
2014.12.03
申请国别(地区):
KR
年份:
2016
代理人:
摘要:
The present invention relates to compounds according to formula (I) (I) Wherein A 11 to A 14 are each N or CR 11 , CR 12 , CR 13 and CR 14 , and at most two of A in four positions may be simultaneously N; R 1 is selected from the group consisting of C (1-6) alkyl, C (3-6) cycloalkyl, C (3-6) cycloalkyl C ) C (3-6) cycloalkylamino or (di) (C (3-6) cycloalkylC (1-3) alkyl) amino wherein all carbon atoms of the alkyl group are optionally substituted with one or more F, All carbon atoms of the cycloalkyl group are optionally substituted with one or more F or methyl; R 2 and R 3 are independently H, F, methyl, ethyl, hydroxy, methoxy, or R 2 and R 3 together are carbonyl; all alkyl groups, if present, Being; R <; 4 >; is H or C (1-6) alkyl; R 5 is H, hydroxyethyl, methoxyethyl, C (1-6) alkyl, C (6-10) aryl, C (6-10) aryl C (1-3) alkyl, C (1-9) C (3-6) cycloalkyl, C (1-3) alkyl, C (2-5) heteroaryl, (1-2) alkoxy or cyano optionally substituted with one or more F, Cl, C (1-2) alkyl, C (1-2) heterocycloalkyl, Substituted; A sulfonyl group having R 1 is represented by one of R 7 , R 8 or R 9 ; The remaining R 6 -R 14 are independently H, halogen, C (1-3) alkoxy, (di) C (1-3) alkylamino or a C (1-6) alkyl, all of which groups more than 1 F Lt; / RTI >; R 15 and R 16 are independently selected from the group consisting of H, C (1-6) alkyl, C (3-6) cycloalkyl, C (3-6) , C (6-10) arylC (1-3) alkyl, C (1-9) heteroaryl, C (1-9) heteroarylC (1-3) alkyl, C (2-5) heterocycloalkyl Or C (2-5) heterocycloalkyl C (1-3) alkyl, wherein all groups are optionally substituted with one or more F, Cl, C (1-2) alkyl, C (1-2) alkoxy or cyano. Such compounds can be used as inhibitors of ROR gamma and are useful in the treatment of ROR gamma mediated diseases.본 발명은 하기 화학식 I에 따른 화합물에 관한 것이다.<;화학식 I>;상기 식에서: A11 - A14는 각각 N 또는 CR11, CR12, CR13, CR14이며, 단 4개 위치의 A 중 2개 이하는 동시에 N일 수 있고; R1은 C(1-6)알킬, C(3-6)시클로알킬, C(3-6)시클로알킬C(1-3)알킬, (디)C(1-6)알킬아미노, (디)C(3-6)시클로알킬아미노 또는 (디)(C(3-6)시클로알킬C(
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