Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments thereof, vectors, and cells encoding the same are also provided. The antibodies and antigen-binding fragments thereof can inhibit binding of PAC1 to PACAP, and are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine and cluster headache.本發明提供與人類PAC1結合之抗體及其抗原結合片段。亦提供編碼該等抗體及其抗原結合片段之核酸、載體及編碼其之細胞。該等抗體及其抗原結合片段可抑制PAC1與PACAP結合，且適用於多種PAC1相關病症，包括治療及/或預防包括偏頭痛及叢集性頭痛在內之頭痛病症。
