LOOMIS, MARIA-CRISTINA,GARCIA-MARTINEZ, LEON F.,DUTZAR, BENJAMIN H.,ALLISON, DANIEL S.,HENDRIX, KATHERINE LEE,OJALA, ETHAN,FAN, PEI,SMITH, JEFFREY T.L.,LATHAM, JOHN A.,KARASEK, CHARLIE,MULLIGAN, JENNY
申请号：
CA3020839
公开号：
CA3020839A1
申请日:
2017.04.14
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The disclosure provides antibodies and antigen binding fragments thereof having binding specificity for Pituitary Adenylate Cyclase- Activating Polypeptide (PACAP). Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP. Further disclosed are the variable heavy (VH) chain, the variable light (VL) chain, and complementarity determining region (CDR) polypeptide sequences of the antibodies and antigen binding fragments thereof, and the polynucleotides encoding them. Further provided are conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof, and using anti-PACAP antibodies and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation are further disclosed
