Alexander Lifke,Valeria Lifke,Bernd Mueller-Beckmann,Tobias Schnitzer
申请号：
US13443917
公开号：
US20120195903A1
申请日:
2012.04.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The current invention is related to a method for the production of a human monoclonal antibody from a immundeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
