Yashwant M. Deo;Michael Endres;John Treml;Tibor Keler
发明人:
Yashwant M. Deo,Tibor Keler,John Treml,Michael Endres
申请号：
US13397476
公开号：
US09095626B2
申请日:
2012.02.15
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to dendritic cells are disclosed. Also disclosed are bispecifics, immunotoxins and antigen conjugates which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
