COWLEY, Philip,KICZUN, Michael,WISE, Alan,DAVIS, Susan
申请号：
ECPI201686132
公开号：
ECSP16086132A
申请日:
2016.11.07
申请国别(地区):
EC
年份:
2019
代理人:
摘要：
1. To provide a trinitro-2,3-dihydroxy (TDO) and / or indolemina 2,3-dihydroxy (IDA) inhibitors for pharmaceutical use, including the following formulas for x1, X2, X3, x4, X5 (attached to the file), each of which is independently selected from C, N and O； Each atom with a dot line can have a separate double-sided link or a simple link, provided that the value of each atom remains unchanged； each R1, R2, R3, R4, R5 and R7 may or may not exist, and may be equal or different, and be selected from h, and a substituted or unreplaced organic unit is selected.As long as the number of these R groups is so large, the values of x1, X2, X3, x4, and X5 can be retained； one or two R6 groups can exist and be selected as Patir group of H and an organic unit that is replaced or not replaced, provided that there are so many R6 groups that Valencia of the carbon atoms to which they are connected It maintains and is in a position as long as at least one R6 is an organic group (preferably a carbon group or a sulfur group) consisting of an atom doubly linked to an oxygen atom,Or the carbon atom, R-6 is connected to it, and the atom with double link to oxygen atom is also connected with heteromorphic atom.Se proporciona un compuesto inhibidor de la triptófano-2,3-dioxigenasa (TDO) y/o indoleamina 2,3-dioxigenasa (IDO) para su uso en medicina, cuyo compuesto comprende la siguiente Fórmula (se agrega en archivo adjunto) en donde X1, X2, X3, X4, y X5 pueden ser iguales o diferentes y cada uno se selecciona independientemente a partir de C, N y O； cada átomo que tiene una línea de puntos puede tener, independientemente, un enlace doble o un enlace simple, siempre que las valencias en cada átomo se mantengan； cada R1, R2, R3, R4, R5, y R7 pueden estar presentes o ausentes y pueden ser iguales o diferentes y se selecciona a partir de H y un grupo orgánico sustituido o no sustituido, siempre que el número de tales grupos R presentes es tal que las valencias de X1, X2, X3, X4, y X5 se mantienen
